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SEXUALLY TRANSMITTED DISEASES: URETHRITIS
Urethritis is an inflammation of the urethra characterized by mucopurulent or purulent urethral discharge, dysuria, or urethral pruritis. It is usually caused by infection, and patients are asymptomatic in about 50% of cases. The organisms causing urethritis in men typically cause cervicitis in women. However, over 20% of infected women may have urethral infection only.
Urethritis is usually caused by sexually transmitted organisms. Gonococcal urethritis is caused by N. gonorrhoeae, which is isolated in 20% of men with urethritis. In contrast, nongonococcal urethritis may be caused by C. trachomatis, U. urealyticum, Mycoplasma genitalium, M. hominis, Trichomonas vaginalis, and herpes simplex virus. C. trachomatis is isolated in 30% to 50% of nongonococcal urethritis cases.
Clinical Findings
Patients with urethritis may complain of a mucopurulent or purulent urethral discharge, dysuria, or urethral pruritis. Male patients with urethritis may present with prostatitis symptoms such as weak urinary stream, perineal pain, and ejaculatory pain. A sexual history of recent contacts is also important. Nongonococcal urethritis tends to have a more insidious onset and milder symptoms. In cases of gonococcal infection, 3% of patients will develop generalized symptoms such as fever, rash, and polyarthritis.
Men with symptoms of urethritis should have a thorough genital examination. The penis should be assessed for lesions suggestive of warts or herpes. Erythema of the distal urethra may be noted. If there is no spontaneous urethral discharge, the glans penis should be gently squeezed to express fluid. Any fluid should be collected for microscopic examination. Inguinal lymphadenopathy may be present. If there are symptoms suggestive of prostate involvement, a rectal examination should be performed. This is important because prostate involvement may necessitate prolonged antibiotic therapy.
Fever, a pustular or papular rash, and tenosynovitis are signs of gonococcemia. Reiter's syndrome is an autoimmune response that is often seen in cases of urethritis, especially with C. trachomatis infection. Reiter's syndrome manifests as synovitis, non-articular bone pain (especially the heel), iritis, conjunctivitis, and ulcerations of the oral or genital mucosae.
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SEXUALLY TRANSMITTED DISEASES: TREATMENT OF URETHRITIS
Treatment of Gonococcal Urethritis
Because of resistance, the CDC does not recommend the use of fluoroquinolones for infections acquired in Asia or the Pacific (including Hawaii). In addition, the CDC has stated that it is "probably inadvisable" to use fluoroquinolones for infections acquired in California. Antibiotics for the treatment of gonococcal infection include cefixime (Suprax), ceftriaxone (Rocephin), ciprofloxacin (Cipro), levofloxacin (Levaquin), and ofloxacin (Floxin).
Alternative antibiotics for N. gonorrhoeae infection include spectinomycin, ceftizoxime, cefoxitin (with probenicid), cefotaxime, gatifloxacin, norfloxacin, and lomefloxacin. Since co-infection with C. trachomatis occurs in 10% to 30% of gonococcal urethritis cases, treatment for both infections should be provided. A single 2 g dose of azithromycin treats both gonococcal and chlamydial infection, but this is not recommended by the CDC, presumably because of the significant gastrointestinal side effects. Instead, the CDC recommends combining the regimens for gonococcal and nongonoccal urethrits.
Treatment of Nongonococcal Urethritis
The first-line regimens for the treatment of nongonococcal urethritis are either azithromycin Zithromax) in a single 1 g oral dose or doxycycline 100 mg orally twice daily for 7 days. Clearly, azithromycin is a better choice if compliance is an issue, and it even offers the opportunity for directly observed therapy. Alternative treatments for nongonococcal urethritis are 7-day regimens of erythromycin, ofloxacin (Floxin), or levofloxacin (Levaquin). Patients who have persistent symptoms (without treatment) and negative findings on tests for N. gonorrhoeae and C. trachomatis are generally treated for nongonococcal urethritis.
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